Blockers of alpha1-adrenoreceptors (alpha1-blockers)

Blockers of alpha1-adrenoreceptors (alpha1-blockers)

How do alpha-1 blockers work? Drugs of this group block the receptors (nerve endings) to epinephrine located in the blood vessels, and prevent the action of vasoconstrictors (in particular, epinephrine). As a result, blood vessels expand and blood pressure decreases. What are the different types of alpha1 blockers? There are only 3 drugs of this group. Their main difference is the duration of the action. Short-acting drugs include prazosin, long-acting drugs-doxazosin and terazosin. What are alpha1 blockers good for? Alpha…

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Imidazoline Receptor Agonists

Imidazoline Receptor Agonists

How do imidazoline receptor agonists work? Interact with imidazoline receptors in the Central nervous system, and through them participate in the regulation of the tone of the sympathetic nervous system. There is a decrease in the Pressor (increase in blood PRESSURE) action of the sympathetic system, systolic and diastolic blood PRESSURE, peripheral vascular resistance decreases, while the cardiac output and heart rate do not change significantly. What are the current imidazoline receptor agonists? Currently, moxonidine is widely used in medical…

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Angiotensin Receptor Blockers

Angiotensin Receptor Blockers

How do AT1-receptor blockers work? According to the mechanism of action, angiotensin receptor blockers (BAR), as well as ACE inhibitors, affect the ReninAngiotensin system. However, this class works “more targeted”, since it removes the excess effects of angiotensin and aldosterone by blocking the at-receptors that these Pressor (blood PRESSURE-boosting) agents affect. THEY prevent the formation of angiotensin, a substance that causes vasoconstriction, and the vessels expand. As a result, blood pressure decreases. What are AT1-receptor blockers? Currently, there are a…

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Angiotensin-converting enzyme inhibitors (ACE inhibitors)

Angiotensin-converting enzyme inhibitors (ACE inhibitors)

How do ACE inhibitors work? The mechanism of action of ACE inhibitors is complex. Drugs of this group violate (inhibit) the formation of aldosterone and angiotensin, which have a powerful Pressor (increase in blood PRESSURE) effect. These drugs prevent narrowing of blood vessels and as a result reduce blood pressure. In addition, ACE inhibitors have a beneficial effect on the heart, kidneys, metabolism of fats and carbohydrates. What are the different types of ACE inhibitors? In the 70s, the first…

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Calcium Antagonist

Calcium Antagonist

How do calcium antagonists work? Calcium antagonists block the flow of calcium to the muscle cells located in the heart and arteries, causing the muscle fibers to relax, the vessels to expand, leading to a decrease in blood pressure. What are the different types of calcium antagonists? All calcium antagonists can be divided into 3 groups depending on their structure. The first group includes nifedipine, amlodipine, felodipine, lacidipine, and isradipine. These drugs act mainly on blood vessels and somewhat accelerate…

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Beta Blockers

Beta Blockers

This is one of the most popular among cardiologists and therapists class of drugs that are successfully used not only for the treatment of arterial hypertension, but also for many other diseases. Professor W. Blake was awarded the Nobel prize for the development and successful implementation of beta blockers in clinical practice. How do beta blockers work? The mechanism of action of beta-blockers is complex. These drugs act directly on special receptors in the heart and blood vessels, resulting in…

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Diuretics

Diuretics

How do diuretics work? When hypertension occurs in the body of patients with sodium and fluid retention, in this regard, it is of great importance to take diuretics, which increase the release of fluid and sodium from the body. As a result, the volume of circulating blood and extracellular fluid decreases, which leads to a decrease in blood pressure. What diuretics are there? Doctors distinguish 3 types of diuretics: loop, thiazide and potassium-sparing. Loop diuretics are characterized by high strength…

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Drug treatment of arterial hypertension

Drug treatment of arterial hypertension

How do I know if I need to start medication for hypertension? We invite you to answer our questionnaire, which is based on the recommendations of experts of the world Health Organization (who). Note if You have migrated: • stroke • heart attack Check this box if You have identified: • angina • diabetes vascular disease of the legs (“intermittent lameness») • aortic aneurysm impaired renal function Check with your doctor if You have: hypertrophy of the left ventricle of…

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Non-drug Treatments

Non-drug Treatments

Is it possible to reduce blood pressure without the use of drugs? Pay attention! Non-drug program to reduce blood PRESSURE is recommended for all patients regardless of the severity of hypertension and the need for medication. With uncomplicated hypertension (until myocardial infarction, cerebral circulation or renal failure have developed) in patients without comorbidities (for example, diabetes mellitus or coronary heart disease), treatment should begin with non-drug methods. The duration of non-drug treatment before switching to drugs can vary from 6…

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Ultrasound Examination of the Kidneys

Ultrasound Examination of the Kidneys

What kind of research is this? This is the study on the monitor screen of the structure of the kidneys and the state of the vessels of the kidneys. Why? This study allows us to assess the position of the kidneys, their size, the structure of their tissue and pelvis. Ultrasound can detect anomalies of the structure and malformations of the kidneys, stones and cysts, helps to identify a number of kidney diseases that can manifest high blood pressure. Identification…

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